解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Thirty-eight survivors from among 117 patients hospitalized after out-of-hospital cardiac arrest were evaluated approximately 3 1/2 years later. Twenty patients were living; 18 had died. Fifty-three percent had resumed independent social activities, but only 32% had returned to work. Eight of 14 patients tested were n...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.12.1298
更新日期:1980-12-01 00:00:00
abstract::Erythrocyte calcium transport as a function of free [Ca++] was examined using inside-out vesicles from eight pairs of patients with Duchenne dystrophy and age- and sex-matched controls. The Km for Ca++ of the transport protein and the Vmax were higher in the Duchenne vesicles in seven of the eight pairs. The mean Km a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.11.1236
更新日期:1980-11-01 00:00:00
abstract::A patient with glioblastoma of the rostral brainstem and hypothalamus exhibited bilateral internuclear ophthalmoplegia and vertical nystagmus; he suffered episodes of cataplexy, narcolepsy, and sleep paralysis. A peculiar fluctuation of posture and tone ("limp man syndrome") proved to be a manifestation of continuous ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.10.1115
更新日期:1980-10-01 00:00:00
abstract::In seven of eight patients with progressive multiple sclerosis subjected to long-term plasmapheresis in combination with azathioprine and pulsed prednisone therapy, we found modest improvement of neurologic function. There was no change in auditory and visual evoked responses or serum demyelinating activity. In six of...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.10.1023
更新日期:1980-10-01 00:00:00
abstract::The clinical and angiographic correlations of small deep infarcts seen on computed tomography (CT) scan were studied in 297 consecutive patients. Some of these showed the features described by Fisher as part of the lacunar syndrome. In a large number, a source of emboli from either a cardiac or a carotid source was hi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.10.1090
更新日期:1980-10-01 00:00:00
abstract::A young girl who initially presented with jaw hypomobility at age 4 years subsequently developed signs of a slowly progressive myopathy. Rods were found in all sampled muscles, and were associated with fibrous contractures in the temporomandibular joint muscles. Rods in fibers undergoing necrosis displayed a pattern o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.9.971
更新日期:1980-09-01 00:00:00
abstract::Homolateral ataxia and crural paresis is a recognized vascular syndrome. However, confirmation of the causative lesion rests principally on one earlier case with multiple other infarcts. We studied a patient with the clinical syndrome; computerized tomography revealed a lucency that appeared within 1 week of the infar...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.9.1013
更新日期:1980-09-01 00:00:00
abstract::The forearm segment of the ulnar nerve is difficult to assess if the nerve has been injured severely at the wrist. A new, simple nerve conduction technique of recording from the sensory dorsal branch of the nerve localizes the lesion and enables easier evaluation of that segment than do other techniques. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.8.873
更新日期:1980-08-01 00:00:00
abstract::An improved agarose gel electrophoretic technique was used to fractionate serum and cerebrospinal fluid (CSF) proteins in patients with presenile dementia. The CSF electrophoretic patterns demonstrated three abnormal bands in the gamma-globulin region in five out of eight of these patients. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.8.882
更新日期:1980-08-01 00:00:00
abstract::Normal human quadriceps muscle was transplanted into nude mice subcutaneously for periods of 1, 2, 3, 4, 6, and 8 weeks. At 1 week, there was myoblast and myotube formation with thin and thick filaments. After 2 weeks, there was myotube formation with partially cross-striated myofilaments, and formation of dyads or tr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.7.740
更新日期:1980-07-01 00:00:00
abstract::Although the ultimate diagnosis of multiple sclerosis (MS) still remains clinical, confirmatory laboratory aids can be of marked assistance, especially in early and atypical cases. Whereas numerous tests have been described, the only ones to withstand scrutiny in numerous laboratories have been various immunoglobulin ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.30.7_part_2.106
更新日期:1980-07-01 00:00:00
abstract::There are multiple difficulties in evaluating new treatments for multiple sclerosis (MS). The clinical diagnosis is imprecise, and the correlation between lesion and clinical dysfunction is incomplete. The neurologic evaluation is complex and lacks full precision. The course of MS is complex and has limited predictabi...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.30.7_part_2.8
更新日期:1980-07-01 00:00:00
abstract::Factors affecting osmotic fragility were studied in red blood cells of patients with Duchenne muscular dystrophy. The mean osmotic fragility (MOF), operationally defined as the NaCl concentration for 50% hemolysis, was found to be higher by 3.63 +/- 0.51 mM in Duchenne cells than in normal cells having an MOF of 60.1 ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.7.726
更新日期:1980-07-01 00:00:00
abstract::Two hypertensive men presented clinically with small, largely unilateral hematomas of the pons and midbrain demonstrated by computerized tomography. Clinical manifestations included "ocular bobbing," complex forms of ophthalmoplegia, Cheyne-Stokes respiration, and pyramidal tract signs. The "typical" sings of massive ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.6.652
更新日期:1980-06-01 00:00:00
abstract::Sera from patients with multiple sclerosis (MS), patients with neurologic diseases other than MS, controls (adult and newborn), and rabbits immunized with bovine oligodendrocytes were assayed for antioligodendrocyte antibodies by a binding test with 125I-protein A. The mean binding of 125I-protein A to oligodendrocyte...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.5.540
更新日期:1980-05-01 00:00:00
abstract::Acquired aphasia with convulsive disorder is an unusual condition in childhood, characterized by loss of language function associated with a paroxysmal electroencephalogram. To determine the course and outcome of this disorder, we evaluated nine patients 10 to 28 years after the onset of aphasia. Four patients had rec...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.5.524
更新日期:1980-05-01 00:00:00
abstract::Human cytomegalovirus and herpes simplex virus DNA probes were labeled in vitro and hybridized to the DNA extracted from brains of patients with multiple sclerosis (MS) to detect the presence of genetic information related to these viruses. We were unable to detect any virus-related genetic information complementary t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.5.530
更新日期:1980-05-01 00:00:00
abstract::Arm-diaphragm synkinesis may occur after injury to the proximal portion of the brachial plexus or cervical nerve roots. Regenerating axons of phrenic motor neurons are misdirected to supply limb muscles. Electrodiagnostic investigations of three patients with symptoms referable to upper brachial plexus or cervical roo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.4.339
更新日期:1980-04-01 00:00:00
abstract::The effect of phenytoin (PHT) concentration on the elimination rate of PHT was evaluated in infants, children, and young adults ranging in age from 1 day to 22 years. As PHT concentration increased, the effective half-life (t50%) increased. In eight children, age 7 months to 4.83 years with initial concentrations betw...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.2.196
更新日期:1980-02-01 00:00:00
abstract::The effects of acute ethanol injection on force production were measured in normal and chronic alcoholic rats. Acutely injected normal rats, acutely injected chronic alcoholic rats, and noninjected chronic alcoholic rats were compared with control groups: normal nonalcoholic rats and a dietetically deprived control gr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.2.139
更新日期:1980-02-01 00:00:00
abstract::Conditioning stimuli to the coronal gyrus or periventricular gray matter inhibit the activity of spinal trigeminal neurons. Valproate decreased the corticofugal inhibition of the spinal trigeminal nucleus, as did ethosuximide, trimethadione, and imipramine. Valproate and ethosuximide also decreased the periventricular...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.2.126
更新日期:1980-02-01 00:00:00
abstract::A 60-year-old patient suffered a lethal hemispheric infarction 3 days after angiographically documented occlusion of the ipsilateral cervical internal carotid artery and while receiving anticoagulant therapy. Pathologic evidence is consistent with embolism from the distal "tail" of a propagated carotid thrombus as the...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.1.84
更新日期:1980-01-01 00:00:00
abstract::In a previously unreported family with olivopontocerebellar atrophy, the kindred contained over 600 individuals in five generations. Of 83 offsping of affected individuals who over over 38.8 years of age (the mean age of the onset of disease in this family), 47 had ataxia; there was autosomal dominant transmission. Cl...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.1.12
更新日期:1980-01-01 00:00:00
abstract::In six patients with cryptococcal meningitis, diagnosis was made by routine cytologic examination of cerebrospinal fluid (CSF). A seventh patient had a false-positive cryptococcal antigen titer, and no organism was seen on SCF examination. The patient had herpes simplex encephalitis on brain biopsy. Cytologic examinat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.1.102
更新日期:1980-01-01 00:00:00
abstract::A patient presented with bilateral brachial plexus neuropathy which 2 weeks later evolved into a polyneuropathy involving all four extremities. On further investigation, the patient was found to have systemic lupus erythematosus. Treatment with steroids was accompanied by complete resolution of the neurologic findings...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.12.1633-a
更新日期:1979-12-01 00:00:00
abstract::A 3-year 8-month-old girl died after 14 months of illness characterized by episodes of intermittent ataxia associated with oculomotor palsy, hypotonia, mental confusion, and disturbances of consciousness. In the last 4 months of life, there were signs of liver dysfunction. Pyruvate dehydrogenase and alpha-ketoglutarat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.12.1578
更新日期:1979-12-01 00:00:00
abstract::Intramedullary cysticercosis of the spinal cord is rare; there have been only 26 previous cases. We describe a patient with low back pain, paraparesis, lumbosacral sensory loss, and signs of meningeal irritation. The clinical diagnosis was spinal cord tumor, but at surgery there was a cysticercus cyst within the lumbo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.11.1531
更新日期:1979-11-01 00:00:00
abstract::Large doses of phenytoin were administered on 159 occasions to 139 adult patients. Most patients had had more than three seizures or were in status epilepticus. Based on response to treatment, patients could be divided into two groups. Those with excellent response (recurrent seizures, 10%; mortality, 1%) included kno...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.11.1474
更新日期:1979-11-01 00:00:00
abstract::The clinical and electroencephalographic (EEG) effects of sodium valproate were studied in four patients by means of serial 24-hour EEG recordings and simultaneous hourly determinations of serum drug concentrations. The patients all had frequent clinical seizures and generalized spike-wave discharges. Valproate appear...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.11.1450
更新日期:1979-11-01 00:00:00
abstract::The University of Kentucky provides neurologic services to rural children by a traveling clinic. In 1978, 438 children (including 231 new patients) made 646 clinic visits. The primary diagnoses were appropriate for a neurology clinic; epilepsy was the most common (74 of 231) among new patients. A community survey of s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.9_part_1.1298
更新日期:1979-09-01 00:00:00
abstract::Four patients developed postural tremor after ingestion of sodium valproate. The tremor was recorded by a variable-capacitance transducer and was of the "benign essential" type. The dosages of sodium valproate varied between 1000 mg and 2000 mg daily and serum levels were between 34.9 microgram per milliliter and 154....
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.8.1177
更新日期:1979-08-01 00:00:00
abstract::Although a neuromuscular syndrome has been induced experimentally by vitamin E deficiency, a human syndrome has not yet been documented. This report describes a 7-year-old boy with severe malabsorption since birth who presented with progressive external ophthalmoplegia, proximal muscle weakness, peripheral neuropathy,...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.8.1182
更新日期:1979-08-01 00:00:00
abstract::We present a clinical and morphological study concerning a kindred with slowly progressive X-linked muscular dystrophy (Becker type). Five males were affected; one died of heart failure at age 16. Severe and early cardiac disorder is unusual in this type of muscular dystrophy, and death at such an early age had not be...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.8.1144
更新日期:1979-08-01 00:00:00
abstract::To assess the possible role of amine neurotransmitters in human epilepsy, we measured metabolites of serotonin (5-hydroxyindoleacetic acid [5-HIAA]), dopamine (homovanillic acid [HVA]), and norepinephrine (3-methoxy-4-hydroxyphenylethylene glycol [MHPG]) in the lumbar cerebrospinal fluid (CSF) of patients with partial...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.8.1157
更新日期:1979-08-01 00:00:00
abstract::The authors report a case of hereditary multiple exostoses (HME) with neurologic complications, and review the literature. A 23-year-old man exhibited a worsening spastic paraparesis with sphincter dysfunction. The cranial nerves and the exteroceptive and deep sensations were apparently undamaged. The family history, ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.29.7.973
更新日期:1979-07-01 00:00:00
abstract::A 66-year-old woman with acute idiopathic polyneuritis (Landry-Guillain-Barré [LGB] syndrome) had normal extraocular movements, but her pupils did not react to light or accommodation. This is the first such case to be reported. Pharmacologic testing pointed to postganglionic involvement of parasympathetic and sympathe...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.7.1033
更新日期:1979-07-01 00:00:00
abstract::We studied 10 patients with transient global amnesia (TGA). Routine electroencephalograms (EEGs) were normal in six; two showed mild temporal lobe abnormalities, one had bitemporal delta activity with rare sharp waves, and one showed bioccipital rhythmic theta activity. Nasopharyngeal (NP) recordings were obtained in ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.6.869
更新日期:1979-06-01 00:00:00
abstract::The levels of plasma free carnitine and ketone bodies have been found to fluctuate inversely in fasting individuals without muscle disease. Circulating short-chain acyl-carnitines paralleled beta-hydroxybutyrate levels. A patient with lipid storage myopathy and muscle carnitine deficiency, and his two daughters, devel...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.6.780
更新日期:1979-06-01 00:00:00
abstract::A 11-year-old boy of short stature had recurrent right temporal pounding headaches of 7 months' duration, and progressive visual loss for 3 days. There was a left hemianopia, alexia without agraphia, and diffuse muscle weakness. Investigation established the presence of a mitochondrial myopathy with pyruvate and lacti...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.5.717
更新日期:1979-05-01 00:00:00
abstract::The ability of two noninvasive diagnostic methods--oculoplethysmography-carotid phonoangiography (OPG/CPA) and directional Doppler ultrasonography--to detect extracranial cerebrovascular disease was examined in 400 consecutive studies. Cerebral arteriography was performed in 74 patients. Transient ischemic attack was ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.5.623
更新日期:1979-05-01 00:00:00